The authors have previously shown the potential therapeutic effect of very high-dose intravenous vitamin C (ascorbic add, ascorbate, AA) in the treatment of cancer. We showed 50 percent of tumor cells with vitamin C concentration at 200 mg/dL in dense monolayer cell culture and 400 mg/ dL for the hollow fiber culture model. Since it is difficult to to maintain this high level of vitamin C in blood for long periods of time, we were interested to see if cytotoxicity of cancer cells could be obtained by using lower concentrations of vitamin C in combination with alternating magnetic fields. Low frequency pulsed magnetic fields (LFMF) and rotating magnetic fields (RMF) were used.

The biological effect of electromagnetic field at different levels of intensity and frequencies have been reported previously.7-9'12 It is thought that alternative magnetic fields and induced electric fields alter cell functions by changing cell membranes. Magnetic fields are thought to interfere with cytoplasm enzyme functions by modifying membrane permeability, modifying ion transport and/or ligand- receptor interactions at the cell membrane surface.! Normal cells and cancer cells have different electrical status. Experimental data has shown that growing cells are electrically negative and cancer cells are the most negative of all1 When LFMF was combined with adriaroycm (doxorubicin), cisplatin, mitomycin C, and other chemotherapeutic drugs, LFMF improved the transport of drugs into cells and reduced the therapeutic dose of these drugs.