Although therapies based on the treatments of metastatic cutaneous melanoma have been tried, the conventional treatment of intravenous and intra-arterial hepatic infusions are usually futile. Systemic chemotherapies may cause temporary shrinkage of a tumor but will not cure the disease. Although the less toxic hepatic arterial infusion increases tumor shrinkage, there is no dear difference in survival rates between the two methods.

Surgeons can resect isolated metastases, however this is not possible in the majority of cases either due to the tumor's size, multicentricity or adjacency to major blood vessels, or inadequacy of the hepatic functional reserve. Palliation is the standard and sole treatment for most patients.