I became interested in vitamin C in 1951 oecause as an antioxidant it inhibits the oxidation of adrenalin to adrenochrome. I used doses of three grams per day and more for my schizophrenic patients. In 1952,1 gave one gram each hour for 48 hours to a woman -who had become psychotic after a mastectomy and had been admitted on a Thursday for electroconvulsive treatment, the only treatment then which had any effectiveness. Monday moming after that vitamin C weekend she was mentally normal and did not need the ECT. At the same time her ulcerated, infected mastectomy lesion had begun to heal. She died six months later from her cancer but mentally normal. This showed that huge doses of vitamin C were tolerable and potentially valuable in treating psychotic patients.

In 1960, a 75-year-old psychotic retired professor was admitted to our psychiatric ward. He had terminal, inoperable lung cancer identified by x-ray and biopsy but he also excreted large amounts of a substance in his irine we had found present in most of our schizophrenic patients. These patients responded well to treatment with vitamin B6. I therefore started him on niacin (B3) 1 g three times daily and the same amount of vitamin C. A few days later he was mentally normal. Every three months his lesion was smaller on x-ray examination and after one year was gone. He died 30 months after I first saw him. A year or two later a 16-year-old female with Ewing's sarcoma was slated for surgery to amputate her arm. I started her on niacinamide Ig three times daily and ascorbic acid 1 g three times daily and suggested to the surgeon he postpone surgery. Her cancer disappeared. In 1977, a female with jaundice was found to have a large mass in the head of the pancreas. It was inoperable, was not biopsied because of the danger of spreading the disease and she was advised she might survive six months.