Hormone replacement therapy (HRT) is a well studied and accepted means of preventing disease and the symptoms associated with aging in addition to a reduced production of the hormones estrogen, progesterone, dehydroepandrosterone(DHEA), and testosterone, the production of growth hormone declines with age. Associated with the decline in these hormones is an increase in incidence of cardiovascular disease, osteoporosis and diabetes. In addition, an increased tendency towards central obesity and a decline in total muscle mass are associated with the aging process.2 New research is providing evidence of a protective effect of growth hormone replacement in aging individuals against the aforementioned diseases and body changes. Adverse effects of excess growth hormone have also been documented. These include an increased rate of proliferation of breast and prostate epithelial cells. Research is needed to determine the lowest possible dose of growth hormone that can be used to obtain benefit from this therapy and to limit, the adverse effects.